Cell Senescence Entries for CHAF1B

Cell Types
Colorectal cancer, Melanoma
Cell Lines
A375P, HCT116
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Cairney et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genet 13(8)e1006942 (PubMed)

CHAF1B Gene Information

HGNC symbol
CHAF1B 
Aliases
CAF-1; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7 
Common name
chromatin assembly factor 1 subunit B 
Entrez Id
8208
Description
Chromatin assembly factor I (CAF-I) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair. [provided by RefSeq, Jul 2008].

CHAF1B Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:6260; DNA replication
GO:6334; nucleosome assembly
GO:6335; DNA replication-dependent nucleosome assembly
GO:31497; chromatin assembly
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5829; cytosol
GO:785; chromatin
GO:33186; CAF-1 complex
Function: GO:5515; protein binding
GO:42393; histone binding
GO:51082; unfolded protein binding
GO:3682; chromatin binding
Show all GO terms

Homologs of CHAF1B in Model Organisms

Caenorhabditis elegans
chaf-2
Danio rerio
chaf1b
Drosophila melanogaster
Caf1-105
Mus musculus
Chaf1b
Rattus norvegicus
Chaf1b
Saccharomyces cerevisiae
CAC2
Schizosaccharomyces pombe
SPAC26H5.03

In other databases

CellAge gene expression
  • This gene is present as CHAF1B

External links

OMIM
601245
Ensembl
ENSG00000159259
Entrez Gene
8208
UniGene
75238
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CHAF1B
GeneCards
CHAF1B