Cell Senescence Entries for CHEK1

Cell Types
Colon cancer
Cell Lines
HCT116
Cancer Cell?
Yes
Method
Knockout
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Poehlmann et al. (2011) Cutting edge: Chk1 directs senescence and mitotic catastrophe in recovery from G₂ checkpoint arrest. J Cell Mol Med 15(7)1528-41 (PubMed)

CHEK1 Gene Information

HGNC symbol
CHEK1 
Aliases
CHK1 
Common name
checkpoint kinase 1 
Entrez Id
1111
Description
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011].

CHEK1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:77; DNA damage checkpoint signaling
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:35556; intracellular signal transduction
GO:71260; cellular response to mechanical stimulus
GO:10569; regulation of double-strand break repair via homologous recombination
GO:1901796; regulation of signal transduction by p53 class mediator
And 25 more GO terms
Cellular component: GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:5737; cytoplasm
GO:5856; cytoskeleton
GO:785; chromatin
GO:5694; chromosome
GO:5615; extracellular space
GO:5815; microtubule organizing center
GO:5813; centrosome
And 5 more GO terms
Function: GO:4672; protein kinase activity
GO:5524; ATP binding
GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:19904; protein domain specific binding
GO:35402; histone kinase activity (H3-T11 specific)
And 1 more GO terms
Show all GO terms

Homologs of CHEK1 in Model Organisms

Caenorhabditis elegans
chk-1
Danio rerio
chek1
Drosophila melanogaster
SNF1A
Mus musculus
Chek1
Rattus norvegicus
Chek1
Saccharomyces cerevisiae
CHK1
Schizosaccharomyces pombe
chk1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as chk-1
  • A homolog of this gene for Drosophila melanogaster is present as SNF1A
CellAge gene expression
  • This gene is present as CHEK1

External links

OMIM
603078
Ensembl
ENSG00000149554
Entrez Gene
1111
UniGene
595920
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CHEK1
GeneCards
CHEK1