Cell Senescence Entries for CPT1C

Cell Types
Breast cancer, Pancreas cancer
Cell Lines
MDA-MB-231, PANC-1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Guan et al. (2019) Effects of carnitine palmitoyltransferases on cancer cellular senescence. J Cell Physiol 234(2)1707-1719 (PubMed)

CPT1C Gene Information

HGNC symbol
CPT1C 
Aliases
CATL1; CPT1P; CPTIC; FLJ23809 
Common name
carnitine palmitoyltransferase 1C 
Entrez Id
126129
Description
This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein regulates the beta-oxidation and transport of long-chain fatty acids into mitochondria, and may play a role in the regulation of feeding behavior and whole-body energy homeostasis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].

CPT1C Ontologies

Gene Ontology
Process: GO:6629; lipid metabolic process
GO:6631; fatty acid metabolic process
GO:6635; fatty acid beta-oxidation
GO:9437; carnitine metabolic process
GO:99072; regulation of postsynaptic membrane neurotransmitter receptor levels
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5783; endoplasmic reticulum
GO:5739; mitochondrion
GO:5741; mitochondrial outer membrane
GO:30054; cell junction
GO:42995; cell projection
GO:30425; dendrite
GO:45202; synapse
GO:30424; axon
GO:5789; endoplasmic reticulum membrane
And 5 more GO terms
Function: GO:16740; transferase activity
GO:4095; carnitine O-palmitoyltransferase activity
GO:16746; acyltransferase activity
GO:5515; protein binding
Show all GO terms

Homologs of CPT1C in Model Organisms

Caenorhabditis elegans
cpt-1
Drosophila melanogaster
whd
Mus musculus
Cpt1c
Rattus norvegicus
Cpt1c

External links

OMIM
608846
Ensembl
ENSG00000169169
Entrez Gene
126129
UniGene
112195
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CPT1C
GeneCards
CPT1C