Cell Senescence Entries for CTNNB1

Cell Types
Bone marrow mesenchymal stem
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Gu et al. (2014) Wnt/β-catenin signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients through the p53/p21 pathway. Mol Cell Biochem 387(1-2)27-37 (PubMed)

CTNNB1 Gene Information

HGNC symbol
CTNNB1 
Aliases
armadillo; beta-catenin; CTNNB 
Common name
catenin beta 1 
Entrez Id
1499
Description
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016].

CTNNB1 Ontologies

Gene Ontology
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:7155; cell adhesion
GO:16055; Wnt signaling pathway
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:7399; nervous system development
GO:43065; positive regulation of apoptotic process
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:209; protein polyubiquitination
GO:9410; response to xenobiotic stimulus
GO:8285; negative regulation of cell population proliferation
And 175 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:16020; membrane
GO:5886; plasma membrane
GO:5856; cytoskeleton
GO:5925; focal adhesion
GO:5829; cytosol
GO:5912; adherens junction
GO:30054; cell junction
GO:42995; cell projection
GO:45202; synapse
And 40 more GO terms
Function: GO:5515; protein binding
GO:45296; cadherin binding
GO:3713; transcription coactivator activity
GO:19899; enzyme binding
GO:8022; protein C-terminus binding
GO:44325; transmembrane transporter binding
GO:19903; protein phosphatase binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:16922; nuclear receptor binding
GO:8013; beta-catenin binding
GO:70411; I-SMAD binding
And 11 more GO terms
Show all GO terms

Homologs of CTNNB1 in Model Organisms

Danio rerio
ctnnb1
Drosophila melanogaster
arm
Mus musculus
Ctnnb1
Rattus norvegicus
Ctnnb1

In other databases

GenAge human genes
  • This gene is present as CTNNB1

External links

OMIM
116806
Ensembl
ENSG00000168036
Entrez Gene
1499
UniGene
712929
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CTNNB1
GeneCards
CTNNB1