Cell Senescence Entries for CXCL1

Cell Types
Ovarian fibroblast
Cell Lines
NOF150
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Yang et al. (2006) The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis. Proc Natl Acad Sci U S A 103(44)16472-7 (PubMed)

CXCL1 Gene Information

HGNC symbol
CXCL1 
Aliases
FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3; SCYB1 
Common name
C-X-C motif chemokine ligand 1 
Entrez Id
2919
Description
This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014].

CXCL1 Ontologies

Gene Ontology
Process: GO:50790; regulation of catalytic activity
GO:6955; immune response
GO:6935; chemotaxis
GO:6954; inflammatory response
GO:6952; defense response
GO:71222; cellular response to lipopolysaccharide
GO:7399; nervous system development
GO:7186; G protein-coupled receptor signaling pathway
GO:7165; signal transduction
GO:30593; neutrophil chemotaxis
GO:70098; chemokine-mediated signaling pathway
And 5 more GO terms
Cellular component: GO:5576; extracellular region
GO:5615; extracellular space
GO:35580; specific granule lumen
GO:1904724; tertiary granule lumen
Function: GO:5515; protein binding
GO:5125; cytokine activity
GO:8083; growth factor activity
GO:8009; chemokine activity
GO:5102; signaling receptor binding
GO:45236; CXCR chemokine receptor binding
GO:8047; enzyme activator activity
Show all GO terms

Homologs of CXCL1 in Model Organisms

Mus musculus
Cxcl3
Rattus norvegicus
Cxcl3

External links

OMIM
155730
Ensembl
ENSG00000163739
Entrez Gene
2919
UniGene
708652
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CXCL1
GeneCards
CXCL1