Cell Senescence Entries for CYP26A1

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Osanai et al. (2016) The retinoic acid-metabolizing enzyme CYP26A1 upregulates fascin and promotes the malignant behavior of breast carcinoma cells. Oncol Rep 34(2)850-8 (PubMed)

CYP26A1 Gene Information

HGNC symbol
CYP26A1 
Aliases
CP26; CYP26; P450RAI; P450RAI1 
Common name
cytochrome P450 family 26 subfamily A member 1 
Entrez Id
1592
Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008].

CYP26A1 Ontologies

Gene Ontology
Process: GO:6629; lipid metabolic process
GO:6805; xenobiotic metabolic process
GO:6766; vitamin metabolic process
GO:16125; sterol metabolic process
GO:34653; retinoic acid catabolic process
GO:42573; retinoic acid metabolic process
GO:48387; negative regulation of retinoic acid receptor signaling pathway
GO:1822; kidney development
GO:32526; response to retinoic acid
GO:33189; response to vitamin A
Cellular component: GO:16020; membrane
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:43231; intracellular membrane-bounded organelle
Function: GO:46872; metal ion binding
GO:4497; monooxygenase activity
GO:16491; oxidoreductase activity
GO:5506; iron ion binding
GO:16705; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:20037; heme binding
GO:16709; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:1972; retinoic acid binding
GO:8401; retinoic acid 4-hydroxylase activity
GO:19825; oxygen binding
GO:62182; all-trans retinoic acid 4-hydrolase activity
And 2 more GO terms
Show all GO terms

Homologs of CYP26A1 in Model Organisms

Danio rerio
cyp26a1
Mus musculus
Cyp26a1
Rattus norvegicus
Cyp26a1
Schizosaccharomyces pombe
erg5

External links

OMIM
602239
Ensembl
ENSG00000095596
Entrez Gene
1592
UniGene
150595
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CYP26A1
GeneCards
CYP26A1