Cell Senescence Entries for DAO
- Cell Types
- Foreskin fibroblast, Osteosarcoma
- Cell Lines
- HS68, U2OS
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Stress-induced
- Senescence Effect
- Induces
- Primary Reference
- Nagano et al. (2018) Identification of cellular senescence-specific genes by comparative transcriptomics. Sci Rep 6(2)31758 (PubMed)
DAO Gene Information
- HGNC symbol
- DAO
- Aliases
- DAAO; DAMOX
- Common name
- D-amino acid oxidase
- Entrez Id
- 1610
- Description
- This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008].
DAO Ontologies
- Gene Ontology
-
Process: GO:19478; D-amino acid catabolic process
GO:46416; D-amino acid metabolic process
GO:42416; dopamine biosynthetic process
GO:6562; proline catabolic process
GO:36088; D-serine catabolic process
GO:55130; D-alanine catabolic process
GO:70178; D-serine metabolic process
GO:6520; cellular amino acid metabolic process
Cellular component: GO:5777; peroxisome
GO:5741; mitochondrial outer membrane
GO:5829; cytosol
GO:5778; peroxisomal membrane
GO:5737; cytoplasm
GO:5782; peroxisomal matrix
Show all GO termsFunction: GO:16491; oxidoreductase activity
GO:3884; D-amino-acid oxidase activity
GO:71949; FAD binding
GO:42802; identical protein binding
GO:5515; protein binding
Homologs of DAO in Model Organisms
- Caenorhabditis elegans
- Y69A2AR.5
- Danio rerio
- dao.3
- Drosophila melanogaster
- CG12338
- Mus musculus
- Dao
- Rattus norvegicus
- Dao
- Schizosaccharomyces pombe
- dao1
External links
- OMIM
- 124050
- Ensembl
- ENSG00000110887
- Entrez Gene
- 1610
- UniGene
- 113227
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- DAO
- GeneCards
- DAO