Cell Senescence Entries for DDAH2

Cell Types
Endothelial progenitor
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Yuan et al. (2015) Regulation of endothelial progenitor cell differentiation and function by dimethylarginine dimethylaminohydrolase 2 in an asymmetric dimethylarginine-independent manner. Cell Biol Int 38(9)1013-22 (PubMed)

DDAH2 Gene Information

HGNC symbol
DDAH2 
Aliases
G6A 
Common name
dimethylarginine dimethylaminohydrolase 2 
Entrez Id
23564
Description
This gene encodes a dimethylarginine dimethylaminohydrolase. The encoded enzyme functions in nitric oxide generation by regulating the cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. The protein may be localized to the mitochondria. Alternative splicing resulting in multiple transcript variants. [provided by RefSeq, Dec 2014].

DDAH2 Ontologies

Gene Ontology
Process: GO:52; citrulline metabolic process
GO:6527; arginine catabolic process
GO:45429; positive regulation of nitric oxide biosynthetic process
GO:43066; negative regulation of apoptotic process
GO:6525; arginine metabolic process
GO:7263; nitric oxide mediated signal transduction
GO:50999; regulation of nitric-oxide synthase activity
GO:6809; nitric oxide biosynthetic process
Cellular component: GO:5737; cytoplasm
GO:5739; mitochondrion
GO:5829; cytosol
GO:70062; extracellular exosome
Function: GO:16787; hydrolase activity
GO:16403; dimethylargininase activity
GO:5515; protein binding
GO:3824; catalytic activity
GO:16597; amino acid binding
Show all GO terms

Homologs of DDAH2 in Model Organisms

Danio rerio
ddah2
Drosophila melanogaster
CG1764
Mus musculus
Ddah2
Rattus norvegicus
Ddah2

External links

OMIM
604744
Ensembl
ENSG00000213722
Entrez Gene
23564
UniGene
247362
1000 Genomes
1000 Genomes
HPRD
GenAtlas
DDAH2
GeneCards
DDAH2