Cell Senescence Entries for DDB1
- Cell Types
- Colorectal cancer, Melanoma
- Cell Lines
- A375P, HCT116
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Cairney et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genet 13(8)e1006942 (PubMed)
DDB1 Gene Information
- HGNC symbol
- DDB1
- Aliases
- Common name
- damage specific DNA binding protein 1
- Entrez Id
- 1642
- Description
- The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012].
DDB1 Ontologies
- Gene Ontology
-
Process: GO:16567; protein ubiquitination
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:48511; rhythmic process
GO:6511; ubiquitin-dependent protein catabolic process
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:45732; positive regulation of protein catabolic process
GO:45070; positive regulation of viral genome replication
GO:10498; proteasomal protein catabolic process
GO:1901990; regulation of mitotic cell cycle phase transition
GO:35518; histone H2A monoubiquitination
And 11 more GO terms Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:5737; cytoplasm
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5615; extracellular space
GO:70062; extracellular exosome
GO:35861; site of double-strand break
GO:80008; Cul4-RING E3 ubiquitin ligase complex
GO:31464; Cul4A-RING E3 ubiquitin ligase complex
GO:31465; Cul4B-RING E3 ubiquitin ligase complex
And 1 more GO terms Function: GO:3676; nucleic acid binding
GO:3677; DNA binding
GO:5515; protein binding
GO:97602; cullin family protein binding
GO:3684; damaged DNA binding
GO:30674; protein-macromolecule adaptor activity
GO:44877; protein-containing complex binding
GO:71987; WD40-repeat domain binding
Homologs of DDB1 in Model Organisms
- Caenorhabditis elegans
- ddb-1
- Drosophila melanogaster
- pic
- Mus musculus
- Ddb1
- Rattus norvegicus
- Ddb1
- Schizosaccharomyces pombe
- ddb1
In other databases
- LongevityMap
- This gene is present as DDB1
External links
- OMIM
- 600045
- Ensembl
- ENSG00000167986
- Entrez Gene
- 1642
- UniGene
- 290758
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- DDB1
- GeneCards
- DDB1