Cell Senescence Entries for AKT3
- Cell Types
- Bladder cancer
- Cell Lines
- EJ138
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Kim et al. (2017) Akt3 knockdown induces mitochondrial dysfunction in human cancer cells. Acta Biochim Biophys Sin (Shanghai) 48(5)447-53 (PubMed)
AKT3 Gene Information
- HGNC symbol
- AKT3
- Aliases
- PKBG; PRKBG; RAC-gamma
- Common name
- AKT serine/threonine kinase 3
- Entrez Id
- 10000
- Description
- The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
AKT3 Ontologies
- Gene Ontology
-
Process: GO:2000773; negative regulation of cellular senescence
GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:35556; intracellular signal transduction
GO:7165; signal transduction
GO:18105; peptidyl-serine phosphorylation
GO:1938; positive regulation of endothelial cell proliferation
GO:90050; positive regulation of cell migration involved in sprouting angiogenesis
GO:43536; positive regulation of blood vessel endothelial cell migration
GO:1905564; positive regulation of vascular endothelial cell proliferation
GO:2; mitochondrial genome maintenance
And 7 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
Homologs of AKT3 in Model Organisms
In other databases
- LongevityMap
- This gene is present as AKT3
External links
- OMIM
- 611223
- Ensembl
- ENSG00000117020
- Entrez Gene
- 10000
- UniGene
- 498292
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- AKT3
- GeneCards
- AKT3