Cell Senescence Entries for DEK

Cell Types
Foreskin keratinocyte
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Wise-Draper et al. (2006) The human DEK proto-oncogene is a senescence inhibitor and an upregulated target of high-risk human papillomavirus E7. J Virol 79(22)14309-17 (PubMed)

DEK Gene Information

HGNC symbol
DEK 
Aliases
D6S231E 
Common name
DEK proto-oncogene 
Entrez Id
7913
Description
This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].

DEK Ontologies

Gene Ontology
Process: GO:6325; chromatin organization
GO:45945; positive regulation of transcription by RNA polymerase III
GO:7165; signal transduction
GO:6366; transcription by RNA polymerase II
GO:6357; regulation of transcription by RNA polymerase II
GO:19079; viral genome replication
GO:6338; chromatin remodeling
GO:2000779; regulation of double-strand break repair
GO:45944; positive regulation of transcription by RNA polymerase II
GO:2001032; regulation of double-strand break repair via nonhomologous end joining
GO:35066; positive regulation of histone acetylation
And 2 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:110016; B-WICH complex
GO:5730; nucleolus
GO:43292; contractile fiber
Function: GO:3723; RNA binding
GO:3677; DNA binding
GO:5515; protein binding
GO:42393; histone binding
Show all GO terms

Homologs of DEK in Model Organisms

Danio rerio
dek
Mus musculus
Dek
Rattus norvegicus
Dek

In other databases

CellAge gene expression
  • This gene is present as DEK

External links

OMIM
125264
Ensembl
ENSG00000124795
Entrez Gene
7913
UniGene
484813
1000 Genomes
1000 Genomes
HPRD
GenAtlas
DEK
GeneCards
DEK