Cell Senescence Entries for DHRS2

Cell Types
Breast cancer, Osteosarcoma
Cell Lines
MCF-7, U2OS
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Oda et al. (2019) Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts. J Cell Sci 131(9)117-26 (PubMed)

DHRS2 Gene Information

HGNC symbol
DHRS2 
Aliases
HEP27; SDR25C1 
Common name
dehydrogenase/reductase 2 
Entrez Id
10202
Description
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members of this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative promoter use and alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017].

DHRS2 Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:8207; C21-steroid hormone metabolic process
GO:8285; negative regulation of cell population proliferation
GO:34599; cellular response to oxidative stress
GO:9636; response to toxic substance
GO:43011; myeloid dendritic cell differentiation
GO:22900; electron transport chain
Cellular component: GO:5654; nucleoplasm
GO:5739; mitochondrion
GO:5634; nucleus
GO:5737; cytoplasm
GO:5759; mitochondrial matrix
GO:5635; nuclear envelope
Function: GO:16491; oxidoreductase activity
GO:5515; protein binding
GO:16616; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:4090; carbonyl reductase (NADPH) activity
Show all GO terms

Homologs of DHRS2 in Model Organisms

Caenorhabditis elegans
dhs-13
Drosophila melanogaster
CG10672
Mus musculus
Dhrs2
Rattus norvegicus
Dhrs2
Schizosaccharomyces pombe
SPAC4H3.08

External links

OMIM
615194
Ensembl
ENSG00000100867
Entrez Gene
10202
UniGene
272499
1000 Genomes
1000 Genomes
HPRD
GenAtlas
DHRS2
GeneCards
DHRS2