Cell Senescence Entries for DIRAS3
- Cell Types
- Adipose progenitor
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Ejaz et al. (2017) Silencing of the small GTPase DIRAS3 induces cellular senescence in human white adipose stromal/progenitor cells. Aging (Albany NY) 9(3)860-879 (PubMed)
DIRAS3 Gene Information
- HGNC symbol
- DIRAS3
- Aliases
- ARHI; NOEY2
- Common name
- DIRAS family GTPase 3
- Entrez Id
- 9077
- Description
- This gene encodes a member of the ras superfamily. This gene is imprinted gene with monoallelic expression of the paternal allele which is associated with growth suppression. The encoded protein acts as a tumor suppressor whose function is abrogated in many ovarian and breast cancers. This protein may also play a role autophagy in certain cancer cells by regulating the autophagosome initiation complex. [provided by RefSeq, Nov 2015].
DIRAS3 Ontologies
- Gene Ontology
-
Process: GO:7165; signal transduction
GO:7264; small GTPase mediated signal transduction
GO:79; regulation of cyclin-dependent protein serine/threonine kinase activity
GO:6349; regulation of gene expression by genetic imprinting
Cellular component: GO:16020; membrane
GO:5886; plasma membrane
Show all GO termsFunction: GO:166; nucleotide binding
GO:3924; GTPase activity
GO:5525; GTP binding
GO:5515; protein binding
GO:19003; GDP binding
Homologs of DIRAS3 in Model Organisms
No homologs found
External links
- OMIM
- 605193
- Ensembl
- ENSG00000162595
- Entrez Gene
- 9077
- UniGene
- 194695
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- DIRAS3
- GeneCards
- DIRAS3