Cell Senescence Entries for DOT1L
- Cell Types
- Lung cancer, Lung fibroblast
- Cell Lines
- A549, IMR-90, NCI-H1299
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Kim et al. (2012) Deficiency of H3K79 histone methyltransferase Dot1-like protein (DOT1L) inhibits cell proliferation. J Biol Chem 287(8)5588-99 (PubMed)
DOT1L Gene Information
- HGNC symbol
- DOT1L
- Aliases
- DOT1; KIAA1814; KMT4
- Common name
- DOT1 like histone lysine methyltransferase
- Entrez Id
- 84444
- Description
- The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011].
DOT1L Ontologies
- Gene Ontology
-
Process: GO:51726; regulation of cell cycle
GO:31507; heterochromatin assembly
GO:34729; histone H3-K79 methylation
GO:32259; methylation
GO:6325; chromatin organization
GO:45893; positive regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:77; DNA damage checkpoint signaling
GO:6281; DNA repair
GO:8284; positive regulation of cell population proliferation
GO:2000677; regulation of transcription regulatory region DNA binding
And 4 more GO terms Cellular component: GO:5634; nucleus
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:32991; protein-containing complex
GO:5737; cytoplasm
Show all GO termsFunction: GO:18024; histone-lysine N-methyltransferase activity
GO:31151; histone methyltransferase activity (H3-K79 specific)
GO:16740; transferase activity
GO:8168; methyltransferase activity
GO:3677; DNA binding
GO:5515; protein binding
GO:3713; transcription coactivator activity
GO:42054; histone methyltransferase activity
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
Homologs of DOT1L in Model Organisms
- Caenorhabditis elegans
- CELE_Y39G10AR.18
- Danio rerio
- dot1l
- Drosophila melanogaster
- gpp
- Mus musculus
- Dot1l
- Rattus norvegicus
- Dot1l
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as dot-1.1
External links
- OMIM
- 607375
- Ensembl
- ENSG00000104885
- Entrez Gene
- 84444
- UniGene
- 713641
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- DOT1L
- GeneCards
- DOT1L