Cell Senescence Entries for DUSP1

Cell Types
Retinoblastoma
Cell Lines
SO-Rb5
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Cheng et al. (2019) DUSP1 promotes senescence of retinoblastoma cell line SO-Rb5 cells by activating AKT signaling pathway. Eur Rev Med Pharmacol Sci 22(22)7628-7632 (PubMed)

DUSP1 Gene Information

HGNC symbol
DUSP1 
Aliases
CL100; HVH1; MKP-1; PTPN10 
Common name
dual specificity phosphatase 1 
Entrez Id
1843
Description
The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017].

DUSP1 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:6470; protein dephosphorylation
GO:16311; dephosphorylation
GO:35335; peptidyl-tyrosine dephosphorylation
GO:1990869; cellular response to chemokine
GO:43409; negative regulation of MAPK cascade
GO:35970; peptidyl-threonine dephosphorylation
GO:43407; negative regulation of MAP kinase activity
GO:90027; negative regulation of monocyte chemotaxis
GO:7162; negative regulation of cell adhesion
GO:1706; endoderm formation
And 6 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
Function: GO:16787; hydrolase activity
GO:4722; protein serine/threonine phosphatase activity
GO:4721; phosphoprotein phosphatase activity
GO:106306; protein serine phosphatase activity
GO:106307; protein threonine phosphatase activity
GO:5515; protein binding
GO:4725; protein tyrosine phosphatase activity
GO:16791; phosphatase activity
GO:8138; protein tyrosine/serine/threonine phosphatase activity
GO:17017; MAP kinase tyrosine/serine/threonine phosphatase activity
GO:51019; mitogen-activated protein kinase binding
And 2 more GO terms
Show all GO terms

Homologs of DUSP1 in Model Organisms

Danio rerio
dusp1
Mus musculus
Dusp1
Rattus norvegicus
Dusp1

In other databases

GenDR gene expression
  • A homolog of this gene for Mus musculus is present as Dusp1

External links

OMIM
600714
Ensembl
ENSG00000120129
Entrez Gene
1843
UniGene
171695
1000 Genomes
1000 Genomes
HPRD
GenAtlas
DUSP1
GeneCards
DUSP1