Cell Senescence Entries for DUSP16
- Cell Types
- Embryonic kidney, Liver cancer
- Cell Lines
- Hep G2, PLC/PRF/5
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Zhang et al. (2016) DUSP16 ablation arrests the cell cycle and induces cellular senescence. FEBS J 282(23)4580-94 (PubMed)
DUSP16 Gene Information
- HGNC symbol
- DUSP16
- Aliases
- KIAA1700; MKP-7; MKP7
- Common name
- dual specificity phosphatase 16
- Entrez Id
- 80824
- Description
- This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010].
DUSP16 Ontologies
- Gene Ontology
-
Process: GO:6470; protein dephosphorylation
GO:16311; dephosphorylation
GO:35335; peptidyl-tyrosine dephosphorylation
GO:43409; negative regulation of MAPK cascade
GO:43508; negative regulation of JUN kinase activity
GO:45204; MAPK export from nucleus
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:31410; cytoplasmic vesicle
GO:5654; nucleoplasm
GO:5829; cytosol
Show all GO termsFunction: GO:16787; hydrolase activity
GO:4722; protein serine/threonine phosphatase activity
GO:4721; phosphoprotein phosphatase activity
GO:106306; protein serine phosphatase activity
GO:106307; protein threonine phosphatase activity
GO:5515; protein binding
GO:4725; protein tyrosine phosphatase activity
GO:16791; phosphatase activity
GO:8138; protein tyrosine/serine/threonine phosphatase activity
GO:17017; MAP kinase tyrosine/serine/threonine phosphatase activity
GO:51019; mitogen-activated protein kinase binding
And 4 more GO terms
Homologs of DUSP16 in Model Organisms
- Caenorhabditis elegans
- vhp-1
- Danio rerio
- dusp16
- Drosophila melanogaster
- puc
- Mus musculus
- Dusp16
- Rattus norvegicus
- Dusp16
In other databases
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as puc
External links
- OMIM
- 607175
- Ensembl
- ENSG00000111266
- Entrez Gene
- 80824
- UniGene
- 536535
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- DUSP16
- GeneCards
- DUSP16