Cell Senescence Entries for ECT2

Cell Types
Colorectal cancer, Melanoma
Cell Lines
A375P, HCT116
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Cairney et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genet 13(8)e1006942 (PubMed)

ECT2 Gene Information

HGNC symbol
ECT2 
Aliases
ARHGEF31 
Common name
epithelial cell transforming 2 
Entrez Id
1894
Description
The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017].

ECT2 Ontologies

Gene Ontology
Process: GO:15031; protein transport
GO:7049; cell cycle
GO:35556; intracellular signal transduction
GO:51301; cell division
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:30154; cell differentiation
GO:7399; nervous system development
GO:43065; positive regulation of apoptotic process
GO:43547; positive regulation of GTPase activity
GO:90630; activation of GTPase activity
GO:281; mitotic cytokinesis
And 15 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5856; cytoskeleton
GO:30054; cell junction
GO:16604; nuclear body
GO:5819; spindle
GO:30496; midbody
GO:32154; cleavage furrow
GO:5923; bicellular tight junction
And 6 more GO terms
Function: GO:5096; GTPase activator activity
GO:42803; protein homodimerization activity
GO:5085; guanyl-nucleotide exchange factor activity
GO:5515; protein binding
GO:31267; small GTPase binding
Show all GO terms

Homologs of ECT2 in Model Organisms

Caenorhabditis elegans
ect-2
Danio rerio
ect2
Drosophila melanogaster
pbl
Mus musculus
Ect2
Rattus norvegicus
Ect2

In other databases

CellAge gene expression
  • This gene is present as ECT2

External links

OMIM
600586
Ensembl
ENSG00000114346
Entrez Gene
1894
UniGene
518299
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ECT2
GeneCards
ECT2