Cell Senescence Entries for EIF2AK3

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Kim et al. (2012) Phenylbutyric acid induces the cellular senescence through an Akt/p21(WAF1) signaling pathway. Biochem Biophys Res Commun 422(2)213-8 (PubMed)

EIF2AK3 Gene Information

HGNC symbol
EIF2AK3 
Aliases
PEK; PERK 
Common name
eukaryotic translation initiation factor 2 alpha kinase 3 
Entrez Id
9451
Description
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015].

EIF2AK3 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:6417; regulation of translation
GO:17148; negative regulation of translation
GO:6986; response to unfolded protein
GO:2063; chondrocyte development
GO:1503; ossification
GO:46777; protein autophosphorylation
GO:1501; skeletal system development
GO:30282; bone mineralization
GO:6919; activation of cysteine-type endopeptidase activity involved in apoptotic process
And 26 more GO terms
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5829; cytosol
GO:30176; integral component of endoplasmic reticulum membrane
GO:48471; perinuclear region of cytoplasm
Function: GO:5524; ATP binding
GO:4672; protein kinase activity
GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:19899; enzyme binding
GO:42802; identical protein binding
And 4 more GO terms
Show all GO terms

Homologs of EIF2AK3 in Model Organisms

Caenorhabditis elegans
pek-1
Danio rerio
eif2ak3
Drosophila melanogaster
PEK
Mus musculus
Eif2ak3
Rattus norvegicus
Eif2ak3

External links

OMIM
604032
Ensembl
ENSG00000172071
Entrez Gene
9451
UniGene
591589
1000 Genomes
1000 Genomes
HPRD
GenAtlas
EIF2AK3
GeneCards
EIF2AK3