Cell Senescence Entries for EIF4G2

Cell Types
Cervical cancer
Cell Lines
HeLa
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Mazan-Mamczarz et al. (2014) Down-regulation of eIF4GII by miR-520c-3p represses diffuse large B cell lymphoma development. PLoS Genet 10(1)e1004105 (PubMed)

EIF4G2 Gene Information

HGNC symbol
EIF4G2 
Aliases
DAP5; NAT1; p97 
Common name
eukaryotic translation initiation factor 4 gamma 2 
Entrez Id
1982
Description
Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008].

EIF4G2 Ontologies

Gene Ontology
Process: GO:6412; translation
GO:6413; translational initiation
GO:6417; regulation of translation
GO:10507; negative regulation of autophagy
GO:51726; regulation of cell cycle
GO:6446; regulation of translational initiation
GO:8219; cell death
GO:30307; positive regulation of cell growth
GO:34645; cellular macromolecule biosynthetic process
GO:7507; heart development
GO:45727; positive regulation of translation
And 4 more GO terms
Cellular component: GO:16020; membrane
GO:5829; cytosol
GO:16281; eukaryotic translation initiation factor 4F complex
GO:5912; adherens junction
GO:30424; axon
GO:5737; cytoplasm
Function: GO:3723; RNA binding
GO:3743; translation initiation factor activity
GO:5515; protein binding
GO:3729; mRNA binding
GO:45296; cadherin binding
GO:8135; translation factor activity, RNA binding
Show all GO terms

Homologs of EIF4G2 in Model Organisms

Danio rerio
eif4g2a
Drosophila melanogaster
NAT1
Mus musculus
Eif4g2
Rattus norvegicus
Eif4g2

External links

OMIM
602325
Ensembl
ENSG00000110321
Entrez Gene
1982
UniGene
183684
1000 Genomes
1000 Genomes
HPRD
GenAtlas
EIF4G2
GeneCards
EIF4G2