Cell Senescence Entries for ENG

Cell Types
Peritoneal mesothelial
Cell Lines
HMR-SV5
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Miao et al. (2016) Endoglin overexpression mediates gastric cancer peritoneal dissemination by inducing mesothelial cell senescence. Hum Pathol 51(2)114-23 (PubMed)

ENG Gene Information

HGNC symbol
ENG 
Aliases
CD105; END; HHT1; ORW; ORW1 
Common name
endoglin 
Entrez Id
2022
Description
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013].

ENG Ontologies

Gene Ontology
Process: GO:7155; cell adhesion
GO:1525; angiogenesis
GO:1569; branching involved in blood vessel morphogenesis
GO:1570; vasculogenesis
GO:1934; positive regulation of protein phosphorylation
GO:1947; heart looping
GO:3148; outflow tract septum morphogenesis
GO:3198; epithelial to mesenchymal transition involved in endocardial cushion formation
GO:3203; endocardial cushion morphogenesis
GO:3208; cardiac ventricle morphogenesis
GO:3209; cardiac atrium morphogenesis
And 51 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:16604; nuclear body
GO:5615; extracellular space
GO:5925; focal adhesion
GO:9986; cell surface
GO:72563; endothelial microparticle
GO:9897; external side of plasma membrane
GO:43235; receptor complex
Function: GO:5515; protein binding
GO:5114; type II transforming growth factor beta receptor binding
GO:42803; protein homodimerization activity
GO:50431; transforming growth factor beta binding
GO:42802; identical protein binding
GO:5024; transforming growth factor beta-activated receptor activity
GO:5539; glycosaminoglycan binding
GO:15026; coreceptor activity
GO:34713; type I transforming growth factor beta receptor binding
GO:48185; activin binding
GO:36122; BMP binding
And 3 more GO terms
Show all GO terms

Homologs of ENG in Model Organisms

Mus musculus
Eng
Rattus norvegicus
Eng

External links

OMIM
131195
Ensembl
ENSG00000106991
Entrez Gene
2022
UniGene
76753
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ENG
GeneCards
ENG