Cell Senescence Entries for ENTPD7

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Tordella et al. (2017) SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer. Genes Dev 30(19)2187-2198 (PubMed)

ENTPD7 Gene Information

HGNC symbol
ENTPD7 
Aliases
FLJ30978; LALP1 
Common name
ectonucleoside triphosphate diphosphohydrolase 7 
Entrez Id
57089
Description
This gene encodes a purine-converting ectoenzyme which belongs to the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. The encoded protein hydrolyzes extracellular nucleoside triphosphates (UTP, GTP, and CTP) to nucleoside monophosphates as part of a purinergic signaling pathway. It contains two transmembrane domains at the N- and C-termini and a large, hydrophobic catalytic domain located in between. This gene affects oxidative stress as well as DNA damage and is a mediator of senescence. [provided by RefSeq, Mar 2017].

ENTPD7 Ontologies

Gene Ontology
Process: GO:34656; nucleobase-containing small molecule catabolic process
GO:46039; GTP metabolic process
GO:9134; nucleoside diphosphate catabolic process
GO:6254; CTP catabolic process
GO:6256; UDP catabolic process
GO:46052; UTP catabolic process
GO:50776; regulation of immune response
GO:72539; T-helper 17 cell differentiation
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:30659; cytoplasmic vesicle membrane
GO:31410; cytoplasmic vesicle
GO:5794; Golgi apparatus
GO:30666; endocytic vesicle membrane
Function: GO:46872; metal ion binding
GO:16787; hydrolase activity
GO:3924; GTPase activity
GO:4382; guanosine-diphosphatase activity
GO:17110; nucleoside-diphosphatase activity
GO:45134; uridine-diphosphatase activity
GO:17111; nucleoside-triphosphatase activity
GO:43273; CTPase activity
Show all GO terms

Homologs of ENTPD7 in Model Organisms

Caenorhabditis elegans
ntp-1
Mus musculus
Entpd7
Rattus norvegicus
Entpd4

External links

OMIM
616753
Ensembl
ENSG00000198018
Entrez Gene
57089
UniGene
744948
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ENTPD7
GeneCards
ENTPD7