Cell Senescence Entries for EPOR

Cell Types
Glioblastoma
Cell Lines
U87
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Pérès et al. (2015) Silencing erythropoietin receptor on glioma cells reinforces efficacy of temozolomide and X-rays through senescence and mitotic catastrophe. Oncotarget 6(4)2101-19 (PubMed)

EPOR Gene Information

HGNC symbol
EPOR 
Aliases
 
Common name
erythropoietin receptor 
Entrez Id
2057
Description
This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010].

EPOR Ontologies

Gene Ontology
Process: GO:19221; cytokine-mediated signaling pathway
GO:7165; signal transduction
GO:8284; positive regulation of cell population proliferation
GO:30097; hemopoiesis
GO:7420; brain development
GO:7507; heart development
GO:38162; erythropoietin-mediated signaling pathway
GO:46697; decidualization
Cellular component: GO:16607; nuclear speck
GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:5576; extracellular region
GO:9897; external side of plasma membrane
GO:5887; integral component of plasma membrane
Function: GO:5515; protein binding
GO:4896; cytokine receptor activity
GO:4888; transmembrane signaling receptor activity
GO:42802; identical protein binding
GO:4900; erythropoietin receptor activity
Show all GO terms

Homologs of EPOR in Model Organisms

Danio rerio
epor
Mus musculus
Epor
Rattus norvegicus
Epor

In other databases

GenAge human genes
  • This gene is present as EPOR

External links

OMIM
133171
Ensembl
ENSG00000187266
Entrez Gene
2057
UniGene
631624
1000 Genomes
1000 Genomes
HPRD
GenAtlas
EPOR
GeneCards
EPOR