Cell Senescence Entries for ERBB2

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Trost et al. (2005) Premature senescence is a primary fail-safe mechanism of ERBB2-driven tumorigenesis in breast carcinoma cells. Cancer Res 65(3)840-9 (PubMed)

ERBB2 Gene Information

HGNC symbol
ERBB2 
Aliases
CD340; HER-2; HER2; NEU; NGL 
Common name
erb-b2 receptor tyrosine kinase 2 
Entrez Id
2064
Description
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].

ERBB2 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:7169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:7165; signal transduction
GO:35556; intracellular signal transduction
GO:71363; cellular response to growth factor stimulus
GO:90314; positive regulation of protein targeting to membrane
GO:30182; neuron differentiation
GO:43547; positive regulation of GTPase activity
GO:14065; phosphatidylinositol 3-kinase signaling
GO:8284; positive regulation of cell population proliferation
And 30 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5829; cytosol
GO:5886; plasma membrane
GO:5768; endosome
GO:10008; endosome membrane
GO:48471; perinuclear region of cytoplasm
GO:5769; early endosome
GO:5887; integral component of plasma membrane
And 9 more GO terms
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:42802; identical protein binding
GO:4713; protein tyrosine kinase activity
GO:4714; transmembrane receptor protein tyrosine kinase activity
GO:5515; protein binding
GO:8022; protein C-terminus binding
And 7 more GO terms
Show all GO terms

Homologs of ERBB2 in Model Organisms

Danio rerio
erbb2
Drosophila melanogaster
Egfr
Mus musculus
Erbb2
Rattus norvegicus
Erbb2

In other databases

GenAge human genes
  • This gene is present as ERBB2
LongevityMap
  • This gene is present as ERBB2

External links

OMIM
164870
Ensembl
ENSG00000141736
Entrez Gene
2064
UniGene
446352
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ERBB2
GeneCards
ERBB2