Cell Senescence Entries for ESR1

Cell Types
Mammary epithelial
Cell Lines
MCF-10A, Primary cell
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Liu et al. (2018) Estrogen receptor alpha inhibits senescence-like phenotype and facilitates transformation induced by oncogenic ras in human mammary epithelial cells. Oncotarget 7(26)39097-39107 (PubMed)

ESR1 Gene Information

HGNC symbol
ESR1 
Aliases
ER-alpha; Era; ESR; NR3A1 
Common name
estrogen receptor 1 
Entrez Id
2099
Description
This gene encodes an estrogen receptor and ligand-activated transcription factor. The canonical protein contains an N-terminal ligand-independent transactivation domain, a central DNA binding domain, a hinge domain, and a C-terminal ligand-dependent transactivation domain. The protein localizes to the nucleus where it may form either a homodimer or a heterodimer with estrogen receptor 2. The protein encoded by this gene regulates the transcription of many estrogen-inducible genes that play a role in growth, metabolism, sexual development, gestation, and other reproductive functions and is expressed in many non-reproductive tissues. The receptor encoded by this gene plays a key role in breast cancer, endometrial cancer, and osteoporosis. This gene is reported to have dozens of transcript variants due to the use of alternate promoters and alternative splicing, however, the full-length nature of many of these variants remain uncertain. [provided by RefSeq, Jul 2020].

ESR1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:43401; steroid hormone mediated signaling pathway
GO:45944; positive regulation of transcription by RNA polymerase II
GO:30522; intracellular receptor signaling pathway
GO:45893; positive regulation of transcription, DNA-templated
GO:10629; negative regulation of gene expression
GO:6338; chromatin remodeling
GO:6367; transcription initiation from RNA polymerase II promoter
GO:6357; regulation of transcription by RNA polymerase II
GO:7165; signal transduction
GO:122; negative regulation of transcription by RNA polymerase II
And 33 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5794; Golgi apparatus
GO:32991; protein-containing complex
GO:5886; plasma membrane
GO:5654; nucleoplasm
GO:785; chromatin
GO:5829; cytosol
GO:5667; transcription regulator complex
And 3 more GO terms
Function: GO:3677; DNA binding
GO:5496; steroid binding
GO:30284; estrogen receptor activity
GO:5515; protein binding
GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:8289; lipid binding
GO:19899; enzyme binding
GO:42802; identical protein binding
And 19 more GO terms
Show all GO terms

Homologs of ESR1 in Model Organisms

Danio rerio
esr1
Mus musculus
Esr1
Rattus norvegicus
Esr1

In other databases

GenAge human genes
  • This gene is present as ESR1
LongevityMap
  • This gene is present as ESR1

External links

OMIM
133430
Ensembl
ENSG00000091831
Entrez Gene
2099
UniGene
744830
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ESR1
GeneCards
ESR1