Cell Senescence Entries for FASTK

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

FASTK Gene Information

HGNC symbol
FASTK 
Aliases
FAST 
Common name
Fas activated serine/threonine kinase 
Entrez Id
10922
Description
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008].

FASTK Ontologies

Gene Ontology
Process: GO:16310; phosphorylation
GO:6915; apoptotic process
GO:43484; regulation of RNA splicing
GO:6468; protein phosphorylation
GO:44528; regulation of mitochondrial mRNA stability
GO:97190; apoptotic signaling pathway
GO:963; mitochondrial RNA processing
Cellular component: GO:5739; mitochondrion
GO:5759; mitochondrial matrix
GO:35770; ribonucleoprotein granule
Function: GO:3723; RNA binding
GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:5515; protein binding
GO:33867; Fas-activated serine/threonine kinase activity
Show all GO terms

Homologs of FASTK in Model Organisms

Danio rerio
fastk
Mus musculus
Fastk
Rattus norvegicus
Fastk

External links

OMIM
606965
Ensembl
ENSG00000164896
Entrez Gene
10922
UniGene
647094
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FASTK
GeneCards
FASTK