Cell Senescence Entries for FBXO22

Cell Types
Colon adenocarcinoma
Cell Lines
HCA-2
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Johmura et al. (2016) SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence. Nat Commun 7(2)10574 (PubMed)

FBXO22 Gene Information

HGNC symbol
FBXO22 
Aliases
FBX22; FISTC1 
Common name
F-box protein 22 
Entrez Id
26263
Description
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010].

FBXO22 Ontologies

Gene Ontology
Process: GO:209; protein polyubiquitination
GO:6464; cellular protein modification process
GO:6511; ubiquitin-dependent protein catabolic process
GO:32436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:6913; nucleocytoplasmic transport
GO:9267; cellular response to starvation
GO:10830; regulation of myotube differentiation
GO:48742; regulation of skeletal muscle fiber development
GO:2000060; positive regulation of ubiquitin-dependent protein catabolic process
Cellular component: GO:5737; cytoplasm
GO:30018; Z disc
GO:5829; cytosol
GO:5634; nucleus
Function: GO:5515; protein binding
GO:4842; ubiquitin-protein transferase activity
Show all GO terms

Homologs of FBXO22 in Model Organisms

Danio rerio
fbxo22
Mus musculus
Fbxo22
Rattus norvegicus
Fbxo22

External links

OMIM
609096
Ensembl
ENSG00000167196
Entrez Gene
26263
UniGene
591115
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FBXO22
GeneCards
FBXO22