Cell Senescence Entries for FBXO31

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Kumar et al. (2006) FBXO31 is the chromosome 16q24.3 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex. Cancer Res 65(24)11304-13 (PubMed)

FBXO31 Gene Information

HGNC symbol
FBXO31 
Aliases
FBX14; Fbx31; FBXO14; MGC15419 
Common name
F-box protein 31 
Entrez Id
79791
Description
This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].

FBXO31 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:16567; protein ubiquitination
GO:6974; cellular response to DNA damage stimulus
GO:31146; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:31145; anaphase-promoting complex-dependent catabolic process
GO:31571; mitotic G1 DNA damage checkpoint signaling
GO:50775; positive regulation of dendrite morphogenesis
GO:2001224; positive regulation of neuron migration
Cellular component: GO:19005; SCF ubiquitin ligase complex
GO:5829; cytosol
GO:43025; neuronal cell body
GO:5813; centrosome
GO:16020; membrane
GO:16021; integral component of membrane
Function: GO:5515; protein binding
GO:30332; cyclin binding
Show all GO terms

Homologs of FBXO31 in Model Organisms

Danio rerio
si:ch211-147k9.7
Mus musculus
Fbxo31
Rattus norvegicus
Fbxo31

External links

OMIM
609102
Ensembl
ENSG00000103264
Entrez Gene
79791
UniGene
658034
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FBXO31
GeneCards
FBXO31