Cell Senescence Entries for ANLN

Cell Types
Breast cancer
Cell Lines
SKBR3
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Magnusson et al. (2017) ANLN is a prognostic biomarker independent of Ki-67 and essential for cell cycle progression in primary breast cancer. BMC Cancer 16(1)904 (PubMed)

ANLN Gene Information

HGNC symbol
ANLN 
Aliases
ANILLIN; scra; Scraps 
Common name
anillin actin binding protein 
Entrez Id
54443
Description
This gene encodes an actin-binding protein that plays a role in cell growth and migration, and in cytokinesis. The encoded protein is thought to regulate actin cytoskeletal dynamics in podocytes, components of the glomerulus. Mutations in this gene are associated with focal segmental glomerulosclerosis 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014].

ANLN Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:51301; cell division
GO:2244; hematopoietic progenitor cell differentiation
GO:281; mitotic cytokinesis
GO:90521; glomerular visceral epithelial cell migration
GO:1904172; positive regulation of bleb assembly
GO:915; actomyosin contractile ring assembly
GO:31106; septin ring organization
GO:921; septin ring assembly
GO:7096; regulation of exit from mitosis
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5856; cytoskeleton
GO:30496; midbody
GO:42995; cell projection
GO:5938; cell cortex
GO:5829; cytosol
GO:32059; bleb
GO:15629; actin cytoskeleton
GO:5826; actomyosin contractile ring
And 1 more GO terms
Function: GO:3779; actin binding
GO:45296; cadherin binding
GO:5515; protein binding
Show all GO terms

Homologs of ANLN in Model Organisms

Caenorhabditis elegans
ani-1
Danio rerio
anln
Drosophila melanogaster
scra
Mus musculus
Anln
Rattus norvegicus
Anlnl1

In other databases

CellAge gene expression
  • This gene is present as ANLN

External links

OMIM
616027
Ensembl
ENSG00000011426
Entrez Gene
54443
UniGene
62180
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ANLN
GeneCards
ANLN