Cell Senescence Entries for FBXO5

Cell Types
Cervical cancer, Colorectal cancer, Retinal pigment epithelial
Cell Lines
HCT116, HeLa, HTERT-RPE1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Verschuren et al. (2008) Loss of Emi1-dependent anaphase-promoting complex/cyclosome inhibition deregulates E2F target expression and elicits DNA damage-induced senescence. Mol Cell Biol 27(22)7955-65 (PubMed)

FBXO5 Gene Information

HGNC symbol
FBXO5 
Aliases
EMI1; FBX5; Fbxo31 
Common name
F-box protein 5 
Entrez Id
26271
Description
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008].

FBXO5 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:16567; protein ubiquitination
GO:51301; cell division
GO:8284; positive regulation of cell population proliferation
GO:7346; regulation of mitotic cell cycle
GO:10971; positive regulation of G2/M transition of mitotic cell cycle
GO:6275; regulation of DNA replication
GO:45669; positive regulation of osteoblast differentiation
GO:7088; regulation of mitotic nuclear division
GO:2000773; negative regulation of cellular senescence
GO:1904667; negative regulation of ubiquitin protein ligase activity
And 14 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5856; cytoskeleton
GO:5819; spindle
GO:5829; cytosol
GO:72687; meiotic spindle
Function: GO:46872; metal ion binding
GO:5515; protein binding
GO:19901; protein kinase binding
GO:10997; anaphase-promoting complex binding
GO:1990948; ubiquitin ligase inhibitor activity
Show all GO terms

Homologs of FBXO5 in Model Organisms

Danio rerio
fbxo5
Mus musculus
Fbxo5
Rattus norvegicus
Fbxo5

In other databases

CellAge gene expression
  • This gene is present as FBXO5

External links

OMIM
606013
Ensembl
ENSG00000112029
Entrez Gene
26271
UniGene
713801
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FBXO5
GeneCards
FBXO5