Cell Senescence Entries for FBXW11

Cell Types
Breast cancer
Cell Lines
SKBR3
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Cui et al. (2021) The cross talk of two family members of β-TrCP in the regulation of cell autophagy and growth. Cell Death Differ 27(3)1119-1133 (PubMed)

FBXW11 Gene Information

HGNC symbol
FBXW11 
Aliases
BTRC2; BTRCP2; Fbw11; Fbw1b; FBXW1B; Hos; KIAA0696 
Common name
F-box and WD repeat domain containing 11 
Entrez Id
23291
Description
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008].

FBXW11 Ontologies

Gene Ontology
Process: GO:209; protein polyubiquitination
GO:6470; protein dephosphorylation
GO:31146; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:42753; positive regulation of circadian rhythm
GO:45893; positive regulation of transcription, DNA-templated
GO:1901223; negative regulation of NIK/NF-kappaB signaling
GO:7049; cell cycle
GO:16567; protein ubiquitination
GO:45892; negative regulation of transcription, DNA-templated
GO:16055; Wnt signaling pathway
GO:48511; rhythmic process
And 11 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:19005; SCF ubiquitin ligase complex
GO:1904115; axon cytoplasm
GO:5813; centrosome
GO:43005; neuron projection
GO:5635; nuclear envelope
GO:43025; neuronal cell body
GO:5881; cytoplasmic microtubule
GO:151; ubiquitin ligase complex
And 3 more GO terms
Function: GO:46983; protein dimerization activity
GO:4842; ubiquitin-protein transferase activity
GO:61630; ubiquitin protein ligase activity
GO:5515; protein binding
GO:70840; dynein complex binding
GO:51010; microtubule plus-end binding
Show all GO terms

Homologs of FBXW11 in Model Organisms

Danio rerio
fbxw11a
Drosophila melanogaster
slmb
Mus musculus
Fbxw11
Schizosaccharomyces pombe
pof11

External links

OMIM
605651
Ensembl
ENSG00000072803
Entrez Gene
23291
UniGene
484138
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FBXW11
GeneCards
FBXW11