Cell Senescence Entries for FGFR2

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Mutation
Type of senescence
Oncogene-induced
Senescence Effect
Unclear
Primary Reference
Ota et al. (2009) The role of senescence and prosurvival signaling in controlling the oncogenic activity of FGFR2 mutants associated with cancer and birth defects. Hum Mol Genet 18(14)2609-21 (PubMed)

FGFR2 Gene Information

HGNC symbol
FGFR2 
Aliases
BEK; CD332; CEK3; CFD1; ECT1; JWS; K-SAM; KGFR; TK14; TK25 
Common name
fibroblast growth factor receptor 2 
Entrez Id
2263
Description
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009].

FGFR2 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:8284; positive regulation of cell population proliferation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:51781; positive regulation of cell division
GO:30177; positive regulation of Wnt signaling pathway
GO:60348; bone development
GO:90263; positive regulation of canonical Wnt signaling pathway
GO:1525; angiogenesis
And 95 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5794; Golgi apparatus
GO:31410; cytoplasmic vesicle
GO:5886; plasma membrane
GO:5576; extracellular region
GO:5938; cell cortex
GO:9986; cell surface
GO:5887; integral component of plasma membrane
And 4 more GO terms
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4713; protein tyrosine kinase activity
GO:4714; transmembrane receptor protein tyrosine kinase activity
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:8201; heparin binding
And 4 more GO terms
Show all GO terms

Homologs of FGFR2 in Model Organisms

Danio rerio
fgfr2
Mus musculus
Fgfr2
Rattus norvegicus
Fgfr2

In other databases

LongevityMap
  • This gene is present as FGFR2

External links

OMIM
176943
Ensembl
ENSG00000066468
Entrez Gene
2263
UniGene
533683
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FGFR2
GeneCards
FGFR2