Cell Senescence Entries for FOXO3

Cell Types
Dermal fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Kyoung Kim et al. (2005) Down-regulation of a forkhead transcription factor, FOXO3a, accelerates cellular senescence in human dermal fibroblasts. J Gerontol A Biol Sci Med Sci 60(1)4-9 (PubMed)

FOXO3 Gene Information

HGNC symbol
FOXO3 
Aliases
AF6q21; FKHRL1; FOXO2; FOXO3A 
Common name
forkhead box O3 
Entrez Id
2309
Description
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008].

FOXO3 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6915; apoptotic process
GO:6417; regulation of translation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:33209; tumor necrosis factor-mediated signaling pathway
GO:6357; regulation of transcription by RNA polymerase II
GO:10508; positive regulation of autophagy
GO:34599; cellular response to oxidative stress
GO:122; negative regulation of transcription by RNA polymerase II
GO:6390; mitochondrial transcription
And 37 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:16020; membrane
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5739; mitochondrion
GO:5759; mitochondrial matrix
GO:5741; mitochondrial outer membrane
GO:5829; cytosol
GO:785; chromatin
GO:90571; RNA polymerase II transcription repressor complex
And 1 more GO terms
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:31490; chromatin DNA binding
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:19901; protein kinase binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:976; transcription cis-regulatory region binding
And 5 more GO terms
Show all GO terms

Homologs of FOXO3 in Model Organisms

Danio rerio
foxo3a
Mus musculus
Foxo3
Rattus norvegicus
Foxo3

In other databases

GenAge human genes
  • This gene is present as FOXO3
GenDR gene manipulations
  • A homolog of this gene for Mus musculus is present as Foxo3
LongevityMap
  • This gene is present as FOXO3

External links

OMIM
602681
Ensembl
ENSG00000118689
Entrez Gene
2309
UniGene
220950
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FOXO3
GeneCards
FOXO3