Cell Senescence Entries for FOXP1

Cell Types
Mesenchymal progenitor
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Li et al. (2017) FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging. J Clin Invest 127(4)1241-1253 (PubMed)

FOXP1 Gene Information

HGNC symbol
FOXP1 
Aliases
12CC4; hFKH1B; HSPC215; QRF1 
Common name
forkhead box P1 
Entrez Id
27086
Description
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

FOXP1 Ontologies

Gene Ontology
Process: GO:10629; negative regulation of gene expression
GO:6355; regulation of transcription, DNA-templated
GO:45892; negative regulation of transcription, DNA-templated
GO:10468; regulation of gene expression
GO:48513; animal organ development
GO:6357; regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:32496; response to lipopolysaccharide
GO:42116; macrophage activation
GO:50727; regulation of inflammatory response
GO:10595; positive regulation of endothelial cell migration
And 20 more GO terms
Cellular component: GO:5634; nucleus
GO:785; chromatin
GO:5654; nucleoplasm
Function: GO:46872; metal ion binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:43621; protein self-association
And 3 more GO terms
Show all GO terms

Homologs of FOXP1 in Model Organisms

Danio rerio
foxp1b
Drosophila melanogaster
CHES-1-like
Mus musculus
Foxp1
Rattus norvegicus
Foxp1

External links

OMIM
605515
Ensembl
ENSG00000114861
Entrez Gene
27086
UniGene
59368
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FOXP1
GeneCards
FOXP1