Cell Senescence Entries for FOXP3
- Cell Types
- Breast cancer, Colon cancer
- Cell Lines
- HCT116, MCF-7
- Cancer Cell?
- Yes
- Method
- Knockdown, Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Induces
- Primary Reference
- Kim et al. (2017) Foxp3 is a key downstream regulator of p53-mediated cellular senescence. Oncogene 36(2)219-230 (PubMed)
FOXP3 Gene Information
- HGNC symbol
- FOXP3
- Aliases
- AIID; DIETER; IPEX; JM2; PIDX; SCURFIN; XPID
- Common name
- forkhead box P3
- Entrez Id
- 50943
- Description
- The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
FOXP3 Ontologies
- Gene Ontology
-
Process: GO:6355; regulation of transcription, DNA-templated
GO:45892; negative regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:6338; chromatin remodeling
GO:6357; regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:8285; negative regulation of cell population proliferation
GO:9615; response to virus
GO:32088; negative regulation of NF-kappaB transcription factor activity
GO:45944; positive regulation of transcription by RNA polymerase II
GO:32689; negative regulation of interferon-gamma production
And 53 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:785; chromatin
Function: GO:46872; metal ion binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:42803; protein homodimerization activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:42826; histone deacetylase binding
And 6 more GO terms
Homologs of FOXP3 in Model Organisms
External links
- OMIM
- 300292
- Ensembl
- ENSG00000049768
- Entrez Gene
- 50943
- UniGene
- 247700
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- FOXP3
- GeneCards
- FOXP3