Cell Senescence Entries for FOXP3

Cell Types
Breast cancer, Colon cancer
Cell Lines
HCT116, MCF-7
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Kim et al. (2017) Foxp3 is a key downstream regulator of p53-mediated cellular senescence. Oncogene 36(2)219-230 (PubMed)

FOXP3 Gene Information

HGNC symbol
FOXP3 
Aliases
AIID; DIETER; IPEX; JM2; PIDX; SCURFIN; XPID 
Common name
forkhead box P3 
Entrez Id
50943
Description
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

FOXP3 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:45892; negative regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:6338; chromatin remodeling
GO:6357; regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:8285; negative regulation of cell population proliferation
GO:9615; response to virus
GO:32088; negative regulation of NF-kappaB transcription factor activity
GO:45944; positive regulation of transcription by RNA polymerase II
GO:32689; negative regulation of interferon-gamma production
And 53 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:785; chromatin
Function: GO:46872; metal ion binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:42803; protein homodimerization activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:42826; histone deacetylase binding
And 6 more GO terms
Show all GO terms

Homologs of FOXP3 in Model Organisms

Drosophila melanogaster
FoxP
Mus musculus
Foxp3
Rattus norvegicus
Foxp3

External links

OMIM
300292
Ensembl
ENSG00000049768
Entrez Gene
50943
UniGene
247700
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FOXP3
GeneCards
FOXP3