Cell Senescence Entries for FXR1

Cell Types
Laryngeal cancer, Tongue cancer
Cell Lines
CAL27, SCC25, SCC4, SCC9, UM-SCC-11A, UM-SCC-11B, UM-SCC-74A, UM-SCC-74B
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Majumder et al. (2017) RNA-Binding Protein FXR1 Regulates p21 and TERC RNA to Bypass p53-Mediated Cellular Senescence in OSCC. PLoS Genet 12(9)e1006306 (PubMed)

FXR1 Gene Information

HGNC symbol
FXR1 
Aliases
 
Common name
FMR1 autosomal homolog 1 
Entrez Id
8087
Description
The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

FXR1 Ontologies

Gene Ontology
Process: GO:6417; regulation of translation
GO:30154; cell differentiation
GO:7517; muscle organ development
GO:60538; skeletal muscle organ development
GO:381; regulation of alternative mRNA splicing, via spliceosome
GO:2000637; positive regulation of gene silencing by miRNA
GO:6915; apoptotic process
GO:1934; positive regulation of protein phosphorylation
GO:51489; regulation of filopodium assembly
GO:17148; negative regulation of translation
GO:43488; regulation of mRNA stability
And 3 more GO terms
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5634; nucleus
GO:36464; cytoplasmic ribonucleoprotein granule
GO:14069; postsynaptic density
GO:43025; neuronal cell body
GO:30424; axon
GO:98793; presynapse
GO:5730; nucleolus
GO:5844; polysome
And 11 more GO terms
Function: GO:3729; mRNA binding
GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:3730; mRNA 3'-UTR binding
GO:46982; protein heterodimerization activity
GO:33592; RNA strand annealing activity
GO:45182; translation regulator activity
Show all GO terms

Homologs of FXR1 in Model Organisms

Danio rerio
fxr1
Drosophila melanogaster
Fmr1
Mus musculus
Fxr1
Rattus norvegicus
LOC100366044

External links

OMIM
600819
Ensembl
ENSG00000114416
Entrez Gene
8087
UniGene
478407
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FXR1
GeneCards
FXR1