Cell Senescence Entries for GEMIN2

Cell Types
Liver cancer
Cell Lines
Huh7
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Ozturk et al. (2006) Reprogramming of replicative senescence in hepatocellular carcinoma-derived cells. Proc Natl Acad Sci U S A 103(7)2178-83 (PubMed)

GEMIN2 Gene Information

HGNC symbol
GEMIN2 
Aliases
SIP1 
Common name
gem nuclear organelle associated protein 2 
Entrez Id
8487
Description
This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011].

GEMIN2 Ontologies

Gene Ontology
Process: GO:6397; mRNA processing
GO:8380; RNA splicing
GO:387; spliceosomal snRNP assembly
GO:245; spliceosomal complex assembly
GO:375; RNA splicing, via transesterification reactions
GO:1905215; negative regulation of RNA binding
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5829; cytosol
GO:16604; nuclear body
GO:5681; spliceosomal complex
GO:32797; SMN complex
GO:34719; SMN-Sm protein complex
GO:97504; Gemini of coiled bodies
Function: GO:5515; protein binding
Show all GO terms

Homologs of GEMIN2 in Model Organisms

Caenorhabditis elegans
smi-1
Danio rerio
gemin2
Drosophila melanogaster
Gem2
Mus musculus
Gemin2
Rattus norvegicus
Gemin2

External links

OMIM
602595
Ensembl
ENSG00000092208
Entrez Gene
8487
UniGene
652307
1000 Genomes
1000 Genomes
HPRD
GenAtlas
GEMIN2
GeneCards
GEMIN2