Cell Senescence Entries for GGCT
- Cell Types
- Breast cancer, Cervical cancer, Glioblastoma, Human epithelial, Prostate cancer
- Cell Lines
- A172, HeLa, LNCaP, MCF-7, MDA-MB-231, PC-3
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Matsumura et al. (2019) Depletion of γ-glutamylcyclotransferase inhibits breast cancer cell growth via cellular senescence induction mediated by CDK inhibitor upregulation. BMC Cancer 16(1)748 (PubMed)
GGCT Gene Information
- HGNC symbol
- GGCT
- Aliases
- C7orf24; CRF21; GCTG; Ggc; MGC3077
- Common name
- gamma-glutamylcyclotransferase
- Entrez Id
- 79017
- Description
- The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].
GGCT Ontologies
- Gene Ontology
-
Process: GO:1836; release of cytochrome c from mitochondria
Cellular component: GO:5829; cytosol
GO:70062; extracellular exosome
Show all GO termsFunction: GO:16829; lyase activity
GO:42803; protein homodimerization activity
GO:3839; gamma-glutamylcyclotransferase activity
Homologs of GGCT in Model Organisms
- Caenorhabditis elegans
- C44B7.7
- Danio rerio
- ggctb
- Drosophila melanogaster
- CG4306
- Mus musculus
- Ggct
- Rattus norvegicus
- Ggct
In other databases
- CellAge gene expression
- This gene is present as GGCT
External links
- OMIM
- 137170
- Ensembl
- ENSG00000006625
- Entrez Gene
- 79017
- UniGene
- 530024
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- GGCT
- GeneCards
- GGCT