Cell Senescence Entries for ARG2

Cell Types
Umbilical vein endothelial, Vascular smooth muscle
Cell Lines
HUVEC, VSMC
Cancer Cell?
No
Method
Mutation, Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Xiong et al. (2014) Arginase-II induces vascular smooth muscle cell senescence and apoptosis through p66Shc and p53 independently of its l-arginine ureahydrolase activity: implications for atherosclerotic plaque vulnerability. J Am Heart Assoc 2(4)e000096 (PubMed)

ARG2 Gene Information

HGNC symbol
ARG2 
Aliases
 
Common name
arginase 2 
Entrez Id
384
Description
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008].

ARG2 Ontologies

Gene Ontology
Process: GO:2376; immune system process
GO:45087; innate immune response
GO:50; urea cycle
GO:1657; ureteric bud development
GO:2829; negative regulation of type 2 immune response
GO:6525; arginine metabolic process
GO:6941; striated muscle contraction
GO:32651; regulation of interleukin-1 beta production
GO:32696; negative regulation of interleukin-13 production
GO:32700; negative regulation of interleukin-17 production
GO:32720; negative regulation of tumor necrosis factor production
And 12 more GO terms
Cellular component: GO:5739; mitochondrion
GO:5737; cytoplasm
GO:5759; mitochondrial matrix
Function: GO:46872; metal ion binding
GO:16787; hydrolase activity
GO:16813; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
GO:5515; protein binding
GO:4053; arginase activity
GO:30145; manganese ion binding
Show all GO terms

Homologs of ARG2 in Model Organisms

Caenorhabditis elegans
CELE_T21F4.1
Danio rerio
arg2
Mus musculus
Arg2
Rattus norvegicus
Arg2
Saccharomyces cerevisiae
CAR1

External links

OMIM
107830
Ensembl
ENSG00000081181
Entrez Gene
384
UniGene
226007
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ARG2
GeneCards
ARG2