Cell Senescence Entries for ARID1B

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Tordella et al. (2017) SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer. Genes Dev 30(19)2187-2198 (PubMed)

ARID1B Gene Information

HGNC symbol
ARID1B 
Aliases
6A3-5; BAF250b; DAN15; ELD/OSA1; KIAA1235; p250R; SMARCF2 
Common name
AT-rich interaction domain 1B 
Entrez Id
57492
Description
This locus encodes an AT-rich DNA interacting domain-containing protein. The encoded protein is a component of the SWI/SNF chromatin remodeling complex and may play a role in cell-cycle activation. The protein encoded by this locus is similar to AT-rich interactive domain-containing protein 1A. These two proteins function as alternative, mutually exclusive ARID-subunits of the SWI/SNF complex. The associated complexes play opposing roles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016].

ARID1B Ontologies

Gene Ontology
Process: GO:6338; chromatin remodeling
GO:2931; response to ischemia
GO:1904385; cellular response to angiotensin
GO:6325; chromatin organization
GO:7399; nervous system development
GO:6357; regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:45815; positive regulation of gene expression, epigenetic
GO:2000045; regulation of G1/S transition of mitotic cell cycle
GO:2000781; positive regulation of double-strand break repair
GO:30071; regulation of mitotic metaphase/anaphase transition
And 6 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:16514; SWI/SNF complex
GO:71565; nBAF complex
GO:70603; SWI/SNF superfamily-type complex
GO:35060; brahma complex
GO:5737; cytoplasm
GO:785; chromatin
GO:71564; npBAF complex
And 2 more GO terms
Function: GO:3677; DNA binding
GO:5515; protein binding
GO:3713; transcription coactivator activity
GO:31491; nucleosome binding
Show all GO terms

Homologs of ARID1B in Model Organisms

Caenorhabditis elegans
let-526
Danio rerio
arid1b
Drosophila melanogaster
osa
Mus musculus
Arid1b
Rattus norvegicus
Arid1b

External links

OMIM
614556
Ensembl
ENSG00000049618
Entrez Gene
57492
UniGene
744461
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ARID1B
GeneCards
ARID1B