Cell Senescence Entries for ASXL2
- Cell Types
- Lung fibroblast
- Cell Lines
- IMR-90
- Cancer Cell?
- No
- Method
- Mutation, Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Daou et al. (2016) The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer. J Biol Chem 290(48)28643-63 (PubMed)
ASXL2 Gene Information
- HGNC symbol
- ASXL2
- Aliases
- ASXH2; FLJ10898; KIAA1685
- Common name
- ASXL transcriptional regulator 2
- Entrez Id
- 55252
- Description
- This gene encodes a member of a family of epigenetic regulators that bind various histone-modifying enzymes and are involved in the assembly of transcription factors at specific genomic loci. Naturally occurring mutations in this gene are associated with cancer in several tissue types (breast, bladder, pancreas, ovary, prostate, and blood). This gene plays an important role in neurodevelopment, cardiac function, adipogenesis, and osteoclastogenesis. [provided by RefSeq, Feb 2017].
ASXL2 Ontologies
- Gene Ontology
-
Process: GO:6355; regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:9887; animal organ morphogenesis
GO:45600; positive regulation of fat cell differentiation
GO:35360; positive regulation of peroxisome proliferator activated receptor signaling pathway
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:35517; PR-DUB complex
Show all GO termsFunction: GO:46872; metal ion binding
GO:3677; DNA binding
GO:3682; chromatin binding
GO:42975; peroxisome proliferator activated receptor binding
GO:5515; protein binding
Homologs of ASXL2 in Model Organisms
External links
- OMIM
- 612991
- Ensembl
- ENSG00000143970
- Entrez Gene
- 55252
- UniGene
- 229304
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ASXL2
- GeneCards
- ASXL2