The ATF6 gene and its putative association with human ageing

Cell Senescence Entries for ATF6

Cell Types: Breast cancer, Foreskin fibroblast
Cell Lines: MCF-7, NHDF
Cancer Cell?: No
Method: Knockdown, Mutation
Type of senescence: Oncogene-induced, Replicative, Stress-induced
Senescence Effect: Induces
Primary Reference: Cormenier et al. (2018) The ATF6α arm of the Unfolded Protein Response mediates replicative senescence in human fibroblasts through a COX2/prostaglandin E2 intracrine pathway. Mech Ageing Dev 170(2)82-91 (PubMed)

ATF6 Gene Information

HGNC symbol: ATF6
Aliases: ATF6A
Common name: activating transcription factor 6
Entrez Id: 22926
Description: This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011].

ATF6 Ontologies

Gene Ontology

Process:

GO:6355; regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:30968; endoplasmic reticulum unfolded protein response
GO:6986; response to unfolded protein
GO:7601; visual perception
GO:6357; regulation of transcription by RNA polymerase II
GO:1654; eye development
GO:7165; signal transduction
GO:43065; positive regulation of apoptotic process
GO:6457; protein folding
GO:36500; ATF6-mediated unfolded protein response

And 5 more GO terms

Cellular component:	GO:5634; nucleus GO:5789; endoplasmic reticulum membrane GO:16020; membrane GO:16021; integral component of membrane GO:5794; Golgi apparatus GO:5783; endoplasmic reticulum GO:139; Golgi membrane GO:785; chromatin GO:5654; nucleoplasm GO:5829; cytosol GO:5635; nuclear envelope
	And 4 more GO terms

Function:

GO:3700; DNA-binding transcription factor activity
GO:35497; cAMP response element binding
GO:3677; DNA binding
GO:5515; protein binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:43565; sequence-specific DNA binding

And 4 more GO terms

Show all GO terms

Homologs of ATF6 in Model Organisms

Caenorhabditis elegans: atf-6
Danio rerio: atf6
Mus musculus: Atf6
Rattus norvegicus: Atf6

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as atf-6

Cell Senescence Entries for ATF6

ATF6 Gene Information

ATF6 Ontologies

Homologs of ATF6 in Model Organisms

In other databases

External links