Cell Senescence Entries for ATF7IP

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Sasai et al. (2014) The transcriptional cofactor MCAF1/ATF7IP is involved in histone gene expression and cellular senescence. PLoS One 8(7)e68478 (PubMed)

ATF7IP Gene Information

HGNC symbol
ATF7IP 
Aliases
FLJ10688; p621 
Common name
activating transcription factor 7 interacting protein 
Entrez Id
55729
Description
ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM, Nov 2010].

ATF7IP Ontologies

Gene Ontology
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:50821; protein stabilization
GO:6355; regulation of transcription, DNA-templated
GO:31647; regulation of protein stability
GO:6306; DNA methylation
GO:90309; positive regulation of DNA methylation-dependent heterochromatin assembly
GO:45898; regulation of RNA polymerase II transcription preinitiation complex assembly
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:16604; nuclear body
GO:5667; transcription regulator complex
Function: GO:5515; protein binding
GO:3714; transcription corepressor activity
GO:16887; ATP hydrolysis activity
GO:3712; transcription coregulator activity
Show all GO terms

Homologs of ATF7IP in Model Organisms

Danio rerio
atf7ip
Drosophila melanogaster
wde
Mus musculus
Atf7ip
Rattus norvegicus
Atf7ip

External links

OMIM
613644
Ensembl
ENSG00000171681
Entrez Gene
55729
UniGene
591151
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ATF7IP
GeneCards
ATF7IP