Cell Senescence Entries for ATG12

Cell Types
Foreskin fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Kang et al. (2012) Autophagy impairment induces premature senescence in primary human fibroblasts. PLoS One 6(8)e23367 (PubMed)

ATG12 Gene Information

HGNC symbol
ATG12 
Aliases
APG12; APG12L 
Common name
autophagy related 12 
Entrez Id
9140
Description
Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 [PubMed 9852036]).[supplied by OMIM, Mar 2008].

ATG12 Ontologies

Gene Ontology
Process: GO:6914; autophagy
GO:45; autophagosome assembly
GO:422; autophagy of mitochondrion
GO:6497; protein lipidation
GO:6501; C-terminal protein lipidation
GO:16236; macroautophagy
GO:32480; negative regulation of type I interferon production
GO:44804; autophagy of nucleus
GO:45824; negative regulation of innate immune response
GO:50687; negative regulation of defense response to virus
GO:1901096; regulation of autophagosome maturation
And 2 more GO terms
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:34045; phagophore assembly site membrane
GO:5829; cytosol
GO:30670; phagocytic vesicle membrane
GO:5776; autophagosome
GO:34274; Atg12-Atg5-Atg16 complex
GO:32991; protein-containing complex
GO:1990234; transferase complex
And 1 more GO terms
Function: GO:5515; protein binding
Show all GO terms

Homologs of ATG12 in Model Organisms

Caenorhabditis elegans
lgg-3
Danio rerio
atg12
Drosophila melanogaster
Atg12
Mus musculus
Atg12
Rattus norvegicus
Atg12
Schizosaccharomyces pombe
atg12

External links

OMIM
609608
Ensembl
ENSG00000145782
Entrez Gene
9140
UniGene
264482
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ATG12
GeneCards
ATG12