Cell Senescence Entries for ATG4D

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Xiao et al. (2019) Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians. Genome Res 28(11)1601-1610 (PubMed)

ATG4D Gene Information

HGNC symbol
ATG4D 
Aliases
APG4-D; APG4D; AUTL4 
Common name
autophagy related 4D cysteine peptidase 
Entrez Id
84971
Description
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

ATG4D Ontologies

Gene Ontology
Process: GO:15031; protein transport
GO:6508; proteolysis
GO:6915; apoptotic process
GO:6914; autophagy
GO:423; mitophagy
GO:34497; protein localization to phagophore assembly site
GO:51697; protein delipidation
Cellular component: GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5739; mitochondrion
GO:5759; mitochondrial matrix
Function: GO:8233; peptidase activity
GO:8234; cysteine-type peptidase activity
GO:16787; hydrolase activity
Show all GO terms

Homologs of ATG4D in Model Organisms

Danio rerio
BX547996.2
Mus musculus
Atg4d
Rattus norvegicus
Atg4d
Saccharomyces cerevisiae
ATG4

External links

OMIM
611340
Ensembl
ENSG00000130734
Entrez Gene
84971
UniGene
512799
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ATG4D
GeneCards
ATG4D