Cell Senescence Entries for ATP6V0A2

Cell Types
Fetal lung fibroblast, Umbilical cord fibroblast
Cell Lines
HUC-F2, TIG-1
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Udono et al. (2016) Impaired ATP6V0A2 expression contributes to Golgi dispersion and glycosylation changes in senescent cells. Sci Rep 5(2)17342 (PubMed)

ATP6V0A2 Gene Information

HGNC symbol
ATP6V0A2 
Aliases
a2; a2V; ATP6a2; ATP6N1D; J6B7; RTF; Stv1; TJ6; TJ6M; TJ6s; Vph1 
Common name
ATPase H+ transporting V0 subunit a2 
Entrez Id
23545
Description
The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V(1) domain for ATP hydrolysis, and an integral membrane V(0) domain for proton translocation. The subunit encoded by this gene is a component of the V(0) domain. Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome. [provided by RefSeq, Jul 2009].

ATP6V0A2 Ontologies

Gene Ontology
Process: GO:6811; ion transport
GO:1902600; proton transmembrane transport
GO:6879; cellular iron ion homeostasis
GO:6955; immune response
GO:16241; regulation of macroautophagy
GO:36295; cellular response to increased oxygen levels
GO:7035; vacuolar acidification
GO:61795; Golgi lumen acidification
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:43231; intracellular membrane-bounded organelle
GO:5886; plasma membrane
GO:5768; endosome
GO:5765; lysosomal membrane
GO:5925; focal adhesion
GO:10008; endosome membrane
GO:220; vacuolar proton-transporting V-type ATPase, V0 domain
GO:33179; proton-transporting V-type ATPase, V0 domain
GO:30670; phagocytic vesicle membrane
And 7 more GO terms
Function: GO:5515; protein binding
GO:46961; proton-transporting ATPase activity, rotational mechanism
GO:51117; ATPase binding
Show all GO terms

Homologs of ATP6V0A2 in Model Organisms

Danio rerio
atp6v0a2a
Mus musculus
Atp6v0a2

External links

OMIM
611716
Ensembl
ENSG00000185344
Entrez Gene
23545
UniGene
25786
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ATP6V0A2
GeneCards
ATP6V0A2