Cell Senescence Entries for ATP6V0C

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Xiao et al. (2019) Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians. Genome Res 28(11)1601-1610 (PubMed)

ATP6V0C Gene Information

HGNC symbol
ATP6V0C 
Aliases
ATP6C; ATP6L; ATPL; VATL; Vma3 
Common name
ATPase H+ transporting V0 subunit c 
Entrez Id
527
Description
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010].

ATP6V0C Ontologies

Gene Ontology
Process: GO:6811; ion transport
GO:1902600; proton transmembrane transport
GO:30177; positive regulation of Wnt signaling pathway
GO:16241; regulation of macroautophagy
GO:15986; ATP synthesis coupled proton transport
GO:7035; vacuolar acidification
GO:7042; lysosomal lumen acidification
GO:48388; endosomal lumen acidification
GO:51452; intracellular pH reduction
GO:61795; Golgi lumen acidification
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5765; lysosomal membrane
GO:5925; focal adhesion
GO:33179; proton-transporting V-type ATPase, V0 domain
GO:5886; plasma membrane
GO:5773; vacuole
GO:70062; extracellular exosome
GO:10008; endosome membrane
GO:70821; tertiary granule membrane
GO:33177; proton-transporting two-sector ATPase complex, proton-transporting domain
And 8 more GO terms
Function: GO:31625; ubiquitin protein ligase binding
GO:5515; protein binding
GO:46961; proton-transporting ATPase activity, rotational mechanism
GO:15078; proton transmembrane transporter activity
GO:46933; proton-transporting ATP synthase activity, rotational mechanism
Show all GO terms

Homologs of ATP6V0C in Model Organisms

Caenorhabditis elegans
vha-1
Danio rerio
atp6v0ca
Drosophila melanogaster
Vha16-3
Mus musculus
Atp6v0c
Rattus norvegicus
Atp6v0c
Saccharomyces cerevisiae
VMA3
Schizosaccharomyces pombe
vma3

In other databases

CellAge gene expression

External links

OMIM
108745
Ensembl
ENSG00000185883
Entrez Gene
527
UniGene
389107
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ATP6V0C
GeneCards
ATP6V0C