Cell Senescence Entries for ATRX

Cell Types
Liposarcoma
Cell Lines
Primary cell
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced, Stress-induced
Senescence Effect
Induces
Primary Reference
Kovatcheva et al. (2017) ATRX is a regulator of therapy induced senescence in human cells. Nat Commun 8(1)386 (PubMed)

ATRX Gene Information

HGNC symbol
ATRX 
Aliases
JMS; MRX52; RAD54; XH2; XNP 
Common name
ATRX chromatin remodeler 
Entrez Id
546
Description
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017].

ATRX Ontologies

Gene Ontology
Process: GO:6325; chromatin organization
GO:6334; nucleosome assembly
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:32508; DNA duplex unwinding
GO:6338; chromatin remodeling
GO:212; meiotic spindle organization
GO:7283; spermatogenesis
GO:10571; positive regulation of nuclear cell cycle DNA replication
GO:30330; DNA damage response, signal transduction by p53 class mediator
And 18 more GO terms
Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:5654; nucleoplasm
GO:5694; chromosome
GO:16604; nuclear body
GO:16605; PML body
GO:43233; organelle lumen
GO:228; nuclear chromosome
GO:779; condensed chromosome, centromeric region
GO:792; heterochromatin
GO:5721; pericentric heterochromatin
And 2 more GO terms
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:3677; DNA binding
GO:16787; hydrolase activity
GO:5515; protein binding
GO:4386; helicase activity
GO:16887; ATP hydrolysis activity
GO:35064; methylated histone binding
GO:3678; DNA helicase activity
GO:140658; ATP-dependent chromatin remodeler activity
And 5 more GO terms
Show all GO terms

Homologs of ATRX in Model Organisms

Danio rerio
atrx
Mus musculus
Atrx

External links

OMIM
300032
Ensembl
ENSG00000085224
Entrez Gene
546
UniGene
653797
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ATRX
GeneCards
ATRX