Cell Senescence Entries for BAG3

Cell Types
Glioma, Laryngeal cancer
Cell Lines
A172, HEp2
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lee et al. (2015) BIS targeting induces cellular senescence through the regulation of 14-3-3 zeta/STAT3/SKP2/p27 in glioblastoma cells. Cell Death Dis 5(2)e1537 (PubMed)

BAG3 Gene Information

HGNC symbol
BAG3 
Aliases
 
Common name
BAG cochaperone 3 
Entrez Id
9531
Description
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008].

BAG3 Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:6915; apoptotic process
GO:6457; protein folding
GO:42307; positive regulation of protein import into nucleus
GO:34605; cellular response to heat
GO:46827; positive regulation of protein export from nucleus
GO:50821; protein stabilization
GO:98840; protein transport along microtubule
GO:8625; extrinsic apoptotic signaling pathway via death domain receptors
GO:45; autophagosome assembly
GO:7420; brain development
And 12 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:16020; membrane
GO:101031; chaperone complex
GO:1725; stress fiber
GO:16235; aggresome
GO:30018; Z disc
GO:43005; neuron projection
Function: GO:5515; protein binding
GO:51087; chaperone binding
GO:45296; cadherin binding
GO:774; adenyl-nucleotide exchange factor activity
GO:44877; protein-containing complex binding
GO:45505; dynein intermediate chain binding
GO:140597; protein carrier activity
Show all GO terms

Homologs of BAG3 in Model Organisms

Danio rerio
bag3
Drosophila melanogaster
stv
Mus musculus
Bag3
Rattus norvegicus
Bag3

External links

OMIM
603883
Ensembl
ENSG00000151929
Entrez Gene
9531
UniGene
523309
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BAG3
GeneCards
BAG3