Cell Senescence Entries for BCL3

Cell Types
Dermal fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Iannetti et al. (2015) Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence. PLoS Genet 10(9)e1004642 (PubMed)

BCL3 Gene Information

HGNC symbol
BCL3 
Aliases
BCL4; D19S37 
Common name
BCL3 transcription coactivator 
Entrez Id
602
Description
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008].

BCL3 Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:6974; cellular response to DNA damage stimulus
GO:45893; positive regulation of transcription, DNA-templated
GO:42981; regulation of apoptotic process
GO:32717; negative regulation of interleukin-8 production
GO:9615; response to virus
GO:32088; negative regulation of NF-kappaB transcription factor activity
GO:6606; protein import into nucleus
GO:45727; positive regulation of translation
GO:7249; I-kappaB kinase/NF-kappaB signaling
And 22 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:43231; intracellular membrane-bounded organelle
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:30496; midbody
GO:48471; perinuclear region of cytoplasm
GO:32996; Bcl3-Bcl10 complex
GO:33257; Bcl3/NF-kappaB2 complex
And 1 more GO terms
Function: GO:5515; protein binding
GO:42826; histone deacetylase binding
GO:140297; DNA-binding transcription factor binding
GO:30674; protein-macromolecule adaptor activity
GO:3714; transcription corepressor activity
GO:3713; transcription coactivator activity
Show all GO terms

Homologs of BCL3 in Model Organisms

Mus musculus
Bcl3
Rattus norvegicus
Bcl3

External links

OMIM
109560
Ensembl
ENSG00000069399
Entrez Gene
602
UniGene
31210
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BCL3
GeneCards
BCL3