Cell Senescence Entries for BCLAF1

Cell Types
Colon cancer
Cell Lines
HCT116, HT-29
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Shao et al. (2016) Bclaf1 is an important NF-κB signaling transducer and C/EBPβ regulator in DNA damage-induced senescence. Cell Death Differ 23(5)865-75 (PubMed)

BCLAF1 Gene Information

HGNC symbol
BCLAF1 
Aliases
BTF; KIAA0164 
Common name
BCL2 associated transcription factor 1 
Entrez Id
9774
Description
This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

BCLAF1 Ontologies

Gene Ontology
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:6915; apoptotic process
GO:2001022; positive regulation of response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:2001244; positive regulation of intrinsic apoptotic signaling pathway
GO:43620; regulation of DNA-templated transcription in response to stress
GO:43065; positive regulation of apoptotic process
GO:2000144; positive regulation of DNA-templated transcription, initiation
GO:1990830; cellular response to leukemia inhibitory factor
GO:6397; mRNA processing
GO:184; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
And 4 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:5654; nucleoplasm
GO:16592; mediator complex
GO:35145; exon-exon junction complex
Function: GO:3723; RNA binding
GO:3677; DNA binding
GO:5515; protein binding
GO:3712; transcription coregulator activity
GO:3729; mRNA binding
Show all GO terms

Homologs of BCLAF1 in Model Organisms

Mus musculus
Bclaf1

External links

OMIM
612588
Ensembl
ENSG00000029363
Entrez Gene
9774
UniGene
486542
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BCLAF1
GeneCards
BCLAF1